Progesterone for Prevention of Recurrent Preterm Labor after Arrested Preterm Labor- A Randomized Controlled Trial

Background: Preterm birth is the major cause of neonatal mortality and morbidity. In developing countries, it’s a major health hazard. But there are very few evidence based interventions to prevent it. This study focus on prevention of preterm birth. Methods: A randomized controlled trial was undertaken in BP Koirala Institute of Health Sciences, where 60 patients were randomized into group 1 (n=29, weekly intramuscular Progesterone) and group 2 (n=31,no treatment) after the arrest of preterm labor with tocolysis. Their latency period till delivery and recurrence of preterm labor and neonatal outcomes were compared. Results: There was significant reduction in recurrence of preterm labor and increase in latency period in progesterone group. However neonatal outcomes were similar. Conclusion: Progesterone is useful in reducing the recurrence of preterm labor in a patient who had preterm labor. *Corresponding author: Mohan C. Regmi, Associate Professor, Department of Obstetrics and Gynecology, BPKIHS, Dharan, Nepal, Tel: 9852049414; E-mail: [email protected] Received June 17, 2012; Accepted July 11, 2012; Published July 17, 2012 Citation: Regmi MC, Rijal P, Agrawal A, Uprety D (2012) Progesterone for Prevention of Recurrent Preterm Labor after Arrested Preterm LaborA Randomized Controlled Trial. Gynecol Obstet 2:125. doi:10.4172/2161-0932.1000125 Copyright: © 2012 Regmi MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.